PD173074

PD173074

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  • $150.00

PD173074 (219580-11-7) is an inhibitor of FGFR tyrosine kinase, and to a lesser extent VEGFR1 (IC50 values are 5 nM, 22.5 nM and 100 nM for FGFR1, FGFR3 and VEGFR respectively). Inhibition of FGFR by PD173074 promotes stem cell self renewal.2,3

References/Citations:

1 Bansal et al. (2003), Specific inhibitor of FGF receptor signaling: FGF-2 mediated effects on proliferation, differentiation and MAPK activation are inhibited by PD173074 in oligodendrocyte-lineage cells; J. Neurosci. Res., 74 486
2) Kim et al. (2012), Regulation of autocrine fibroblast growth factor-2 signaling by perfusion flow in 3D human mesenchymal stem cell constructs; Biotechnol. Prog., 28 1384
3) Zaragosi et al. (2006), Autocrine fibroblast growth factor 2 signaling is critical for self renewal of human multipotent adipose-derived stem cells; Stem Cells, 24 2412

CAS:
219580-11-7

Catalog Number:
10-4505

Activity:
FGFR inhibitor

Chemical Name:
1-t-Butyl-3-(6-(3,5-dimethoxyphenyl)-2-(4-diethylaminobutylamino)-pyrido[2,3-d]pyrimidin-7-yl)urea

Molecular Weight:
523.67

Molecular Formula:
C28H41N7O3

Solubility:
Soluble in DMSO.

Physical Properties:
Yellow solid

Purity:
99% by HPLC
NMR (Conforms)

Storage Temperature:
-20°

Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

Shipping Code:
RT