IM-12

IM-12

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IM-12 (1129669-05-1) is a potent and selective inhibitor of glycogen synthase kinase 3ß  (GSK-3ß) IC50=53 nM which induces neuronal differentiation.1 Activates the Wnt-ß-catenin signaling pathway and attenuates tissue plasminogen activator-induced hemorrhagic transformation after acute ischemic stroke in animal models.2 Promoted hair follicle growth in vitro and antagonized the inhibition of hair follicles by dihydrotestosterone.3 Down-regulates Sox9 expression in limbal epithelial stem/progenitor cells leading to increased differentiation.4

References/Citations:

  1. Schmöle et al. (2010), Novel indolylmaleimide acts as GSK-3beta inhibitor in human neural progenitor cells; Bioorg. Med. Chem., 18 6785
  2. Wang et al. (2019), IM-12 activates the Wnt-ß-catenin signaling pathway and attenuates rtPA-induced hemorrhagic transformation in rats after acute ischemic stroke; Cell Biol., 97 702
  3. Chen et al. (2020), Discovery of the FDA-approved drugs bexarotene, cetilistat, diiodohydroxyquinoline and abiraterone as potential covid-19 treatments with a robust two-tier screening system; Front. Pharmacol., 10 1528
  4. Menzel-Severing et al. (2018), Transcription factor profiling identifies Sox9 as regulator of proliferation and differentiation in corneal epithelial stem/progenitor cells; Sci. Rep., 8 10268
CAS:
1129669-05-1

Catalog Number:
10-5125

Activity:
GSK-3ß inhibitor

Chemical Names:
3-(4-Fluorophenylethylamino)-1-methyl-4-(2-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione

Molecular Weight:
377.41

Molecular Formula:
C22H20FN3O2

Solubility:
Soluble in DMSO (50 mg/ml)

Physical Properties:
Yellow solid

Purity:
98% HPLC
NMR (Conforms)

Storage Temperature:
-20°C

Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.

Shipping Code:
RT