Chroman 1

Chroman 1

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  • $195.00

Chroman 1 (1273579-40-0) is an extremely potent inhibitor of Rho kinase II (ROCK-II)1,2 – it displayed greater selectivity and potency compared to Y-27632 (IC50’s: ROCK I = 52 pM/ROCK II = 1 pM; Y-27632 IC50’s: ROCK I = 71 nM/ROCK II = 46 nM)3.  Chroman 1, used in conjunction with trans-ISRIB (Cat# 10-1539), Emricasan (Cat# 10-4280), and polyamines (CEPT cocktail), promotes cytoprotective cell survival in human pluripotent stem cells (hPSCs) and was found to be superior to Y-27632.3 Chroman 1 is an important new tool in the generation and maintenance of stem cells.

References/Citations:

  1. Chen et al. (2011), Asymmetric synthesis of potent chroman-based Rho kinase (ROCK-II) inhibitors; Med. Chem. Commun.,2 73
  2. Chen et al. (2008), Chroman-3-amides as potent Rho kinase inhibitors; Bioorg. Med. Chem. Lett., 18 6406
  3. Chen et al. (2021), A Versatile Polypharmacology Platform Promotes Cytoprotection and Viability of Human Pluripotent and Differentiated Cells; Nat. Methods, 18 528
CAS:
1273579-40-0

Catalog Number:
10-4912

Activity:
ROCK II inhibitor / Stem cell cytoprotectant

Chemical Names:
(3S)-N-[2,[2-(Dimethylamino)ethoxy)-4-(1H-pyrazol-4-yl)phenyl]-6-methoxy-3,4-dihydro-2H-chromen-3-carboxamide

Molecular Weight:
436.51

Molecular Formula:
C24H28N4O4

Solubility:
Soluble in DMSO (at least 50 mg/ml)

Physical Properties:
White solid

Purity:
99% HPLC
NMR (Conforms)

Storage Temperature:
-20°C

Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.

Shipping Code:
RT