Tranylcypromine (13492-01-8) is an irreversible and non-selective monoamine oxidase inhibitor.1,2 It has been shown to inhibit the histone demethylase BHC110/LSD1.3,4
References/Citations:
1) Knoll et al. (1980), Monoamine oxidase inhibitors: Chemistry and Pharmacology; In, Sandler (ed) Enzyme inhibitors as drugs, MacMillan, London 151
2) Baker et al. (1992), Insights into the mechanisms of action of the MAO inhibitors phenelzine and tranylcypromine; a review, J.Psychiatry Neurosci. 17 206
3) Lee et al. (2006), Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications; Chemistry and Biology, 13 563
4) Schmidt and McCafferty (2007), trans-2-Phenylcyclopropylamine is a Mechanism-Based Inactivator of the Histone Demethylase LSD1; Biochemistry, 46 4408
