Enzymatic Hydrolyzed Fucoidan (Whole Profile Fucoidan)
Fucoidan are a group of mucopolysaccharides isolated from the outer-surface of brown seaweeds. These fucose-containing sulfated polysaccharides (FCSP’s, also call Fucoidan) are found mainly in brown seaweed such as Mozuku, Kombu, Limu moui, Bladderwrack, Wakame and Hijiki. These polysaccharides are also composed of galactose, mannose, or xylose containing sulfate ester bonds. Many researchers have demonstrated that fucoidan exhibits immunomodulatory, anti-tumor, anti-inflammatory, anti-viral, and glucose control activities.
Whole Profile Fucoidan- An unique enzymatic hydrolysis technique gives wider & balanced molecular weight distribution with better bioactivities
The bioactivities of FCSP may vary depending on the source of seaweed, the compositional and structural traits, distribution, and bonding of the sulfate substitutions. The preservation of the structural integrity of the FCSP molecules essentially depend on the extraction methodology (Tutor Ale et. al., 2011). FCSP’s are vulnerable to traditional chemical harsh extraction; therefore, gentler enzymatic hydrolysis extraction techniques which use shorter extraction times, lower temperatures, and lower acid levels will ensure extraction of distinct structures for those FCSP. Most commercial Fucoidan products (Fig. 1) contain only large molecules (100 ~ 2000 kDa) while Simpson Biotech’s Whole Profile Fucoidan (WPF) has not only large molecules, but also mid-size (10 ~ 100 kDa, same dose, better performance) and small (~500Da, easy-absorbed) polysaccharides for all kind of bioactivities.
WPF Effect on Blood Glucose Control
Blood glucose control: Slow down starch digestion
In 2012 about 9.3% of the population in the United States has diabetes most of them are Type2. Type 2 diabetes is caused by an imbalance between blood glucose absorption and insulin secretion. To control Type 2 diabetes, reducing the glucose released from starch digestion processes is a way. Glucose release can be reduced by inhibiting the activity of two major digesting enzymes “α-amylase and α-glucosidase”. α-amylase randomly cleaves the starches into oligosaccharides called dextrin or maltose (disaccharides) while α-glucosidase breaks down disaccharides to glucose. WPF efficiently inhibits α-amylase activity with IC50 of 240.62 μg/ml better than commercial product A (contain polyphenol-rich brown seaweed hydrolysate, as the active ingredient) and Acarbose 50 ( an anti-diabetes drug) as showed in Table 1. The blood glucose control ability in 30kg pigs with starch-based meals of 150mg/pig WPF is even better than that of 500 mg/pig with commercial product A (Figure 2.).