Ro 41-5253 (144092-31-9) is a selective RARα antagonist.1 Binds RARα without inducing transcription or influencing RAR/RXR heterodimerization and DNA binding.2 Ro 415253 inhibits proliferation and induces apoptosis in a variety of cell lines/types. Cell Permeable.
References/Citations:
1) Apfel et al. (1992), A retinoic acid receptor alpha antagonist selectively counteracts retinoic acid effects; Proc. Natl. Acad. Sci. USA, 89 7129
2) Toma et al. (1998), RARα antagonist Ro 41-5253 inhibits proliferation and induces apoptosis in breast-cancer cell lines; Int. J. Cancer, 78 86
