LDN-193189 HCl

LDN-193189 HCl

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LDN-193189 HCl (1435934-00-1) is a potent and selective inhibitor of ALK2 (IC50 = 5 nM) and ALK3 (IC50 = 30 nM), thereby inhibiting SMAD1/5/8 phosphorylation.1  Only weak inhibition of ALK4, ALK5, and ALK7 is observed.  Promotes neuronal differentiation of human pluripotent stem cells.2-3  LDN-193189 HCl has also been used to examine the role of osteogenesis in prostate tumor metastases in bone.4

References/Citations:

1) Yu et al. (2008), BMP type 1 receptor inhibition reduces heterotropic ossification; Nature Med.,14 1363
2) Chambers et al. (2012), Combined small-molecule inhibition accelerates developmental timing and converts human pluripotent stem cells into nociceptors; Nature Biotechnol. 30 715
3) Kreitzer et al. (2013) A robust method to derive functional neural crest cells from human pluripotent stem cells; Am. J. Stem Cells, 2 119
4) Lee et al. (2011) BMP4 promotes prostate tumor growth in bone through osteogenesis; Cancer Res. 71 5194

CAS:
1435934-00-1

Catalog Number:
10-4764

Activity:
Inhibitor of ALK2 and ALK3

Chemical Name:
4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline dihydrochloride

Molecular Weight:
479.40

Molecular Formula:
C25H22N6·2HCl

Solubility:
Soluble in DMSO or in Water (up to 5 mg/ml)

Physical Properties:
Orange-yellow solid

Purity:
99% by HPLC
NMR (Conforms)

Storage Temperature:
-20°C

Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 2 months.

Shipping Code:
RT