ICG-001

ICG-001

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ICG-001 (847591-62-2) inhibits TCF/β-catenin mediated transcription by specifically blocking β-catenin/CBP interaction

References/Citations:

1) Emami et al. (2004), A small molecule inhibitor of β-catenin/CREB-binding protein transcription;  Proc. Natl. Acad. Sci. USA, 101 12682
2) Zhou et al. (2012), Interactions between β-catenin and transforming growth factor-β signaling pathways mediate epithelial-mesenchymal transition and are dependent on the transcription co-activator cAMP-response element-binding protein (CERB)-binding protein (CBP);  J. Biol. Chem., 287 7026

CAS:
847591-62-2

Catalog Number:
10-4378

Activity:
Wnt β-catenin inhibitor

Chemical Name:
(6S,9aS)-Hexahydro-6-[(4-hydroxypheny;)methyl]-8-(1-naphthalenylmethyl)-4,7-dioxo-N-(phenylmethyl)-2H- pyrazine[1,2-a]pyrimidine-1(6H)-carboxamide

Molecular Weight:
548.63

Molecular Formula:
C33H32N4O4

Solubility:
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 25 mg/ml).

Physical Properties:
Off-white solid

Purity:
98% by TLC
NMR (Conforms)

Storage Temperature:
-20°C

Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

Shipping Code:
RT