EX-527

EX-527

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EX-527 (49843-98-3) is a selective SIRT1 inhibitor (IC50=98 nM). Does not inhibit other HDACs or SIRT family members. Increases p53 acetylation following DNA damage. Cell permeable.

References/Citations:

1) Napper et al. (2005), Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1; J. Med. Chem., 48 8045
2) Solomon et al. (2006) Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage; Mol. Cell, 26 28
3) Gertz et al. (2013) EX-527 inhibits Sirtuins by exploiting their unique NAD+-dependent deacetylation mechanism; Proc. Natl. Acad. Sci. USA, 110 e2772

CAS:
49843-98-3

Catalog Number:
10-1083

Activity:
SIRT1 inhibitor

Chemical Name:
6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-xarboxamide (racemic)

Molecular Weight:
248.71

Molecular Formula:
C13H13ClN2O

Solubility:
Soluble in DMSO (up to 18 mg/ml) or in Ethanol (up to 10 mg/ml).

Physical Properties:
Light yellow solid

Purity:
98% by TLC
NMR (Conforms)

Storage Temperature:
-20°C

Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months

Shipping Code:
RT