Everolimus

Everolimus

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Everolimus (159351-69-6) is a semisynthetic analog of rapamycin (Cat.# 10-1104) with potent immunosuppressive activity.1 Inhibits mTOR.2 Everolimus is a clinically useful immunosuppressant.3

References/Citations:

1) Schuurman et al. (1997), SDZ RAD, a new rapamycin derivative: synergism with cyclosporine; Transplantation, 64 32
2) Neuhaus et al. (2001), mTOR inhibitors: an overview; Liver Transpl., 7 473
3) Kahan et al. (2002), Therapeutic drug monitoring of immunosuppressant drugs in clinical practice; Clin. Ther., 24 330

CAS:
159351-69-6

Catalog Number:
10-2136

Activity:
mTOR inhibitor

Alternate Names:
SDZ RAD; RAD001

Chemical Name:
40-O-(2-Hydroxyethyl)rapamycin

Molecular Weight:
958.25

Molecular Formula:
C53H84NO14

Solubility:
Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 100 mg/ml).

Physical Properties:
White solid

Purity:
98% by TLC
NMR (Conforms)

Storage Temperature:
-20°

Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.

Shipping Code:
RT