Cyclopamine

Cyclopamine

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Cyclopamine (4449-51-8) is a naturally occurring steroidal alkaloid with teratogenic activity. Blocks sonic hedgehog signaling by binding to smoothened. Antitumor activity. Cell Permeable.

References/Citations:

1) Watkins et al. (2003), Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer; Nature, 422 313

CAS:
4449-51-8

Catalog Number:
10-1082

Activity:
Inhibits hedgehog signaling

Molecular Weight:
411.63

Molecular Formula:
C27H41NO2

Solubility:
Soluble in DMSO (up to 4 mg/ml) or in Ethanol (up to 20 mg/ml)

Physical Properties:
White solid

Purity:
98% by TLC
NMR (Conforms)

Storage Temperature:
-20°C

Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

Shipping Code:
RT